In Vitro Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis
Identifieur interne : 004585 ( Main/Exploration ); précédent : 004584; suivant : 004586In Vitro Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis
Auteurs : Jan Kazenwadel [Australie] ; Genevieve A. Secker [Australie] ; Kelly L. Betterman [Australie] ; Natasha L. Harvey [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Despite the importance of blood vessels and lymphatic vessels during development and disease, the signalling pathways underpinning vessel construction remain poorly characterised. Primary mouse endothelial cells have traditionally proven difficult to culture and as a consequence, few assays have been developed to dissect gene function and signal transduction pathways in these cells
Url:
DOI: 10.1371/journal.pone.0040497
PubMed: 22792354
PubMed Central: 3391274
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004442
- to stream Pmc, to step Curation: 004441
- to stream Pmc, to step Checkpoint: 002C25
- to stream Ncbi, to step Merge: 004F45
- to stream Ncbi, to step Curation: 004F45
- to stream Ncbi, to step Checkpoint: 004F45
- to stream Main, to step Merge: 004609
- to stream Main, to step Curation: 004585
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>In Vitro</italic>
Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis</title>
<author><name sortKey="Kazenwadel, Jan" sort="Kazenwadel, Jan" uniqKey="Kazenwadel J" first="Jan" last="Kazenwadel">Jan Kazenwadel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Secker, Genevieve A" sort="Secker, Genevieve A" uniqKey="Secker G" first="Genevieve A." last="Secker">Genevieve A. Secker</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Betterman, Kelly L" sort="Betterman, Kelly L" uniqKey="Betterman K" first="Kelly L." last="Betterman">Kelly L. Betterman</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Medicine, University of Adelaide, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harvey, Natasha L" sort="Harvey, Natasha L" uniqKey="Harvey N" first="Natasha L." last="Harvey">Natasha L. Harvey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Medicine, University of Adelaide, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22792354</idno>
<idno type="pmc">3391274</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391274</idno>
<idno type="RBID">PMC:3391274</idno>
<idno type="doi">10.1371/journal.pone.0040497</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">004442</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004442</idno>
<idno type="wicri:Area/Pmc/Curation">004441</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004441</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002C25</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002C25</idno>
<idno type="wicri:Area/Ncbi/Merge">004F45</idno>
<idno type="wicri:Area/Ncbi/Curation">004F45</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004F45</idno>
<idno type="wicri:Area/Main/Merge">004609</idno>
<idno type="wicri:Area/Main/Curation">004585</idno>
<idno type="wicri:Area/Main/Exploration">004585</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>In Vitro</italic>
Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis</title>
<author><name sortKey="Kazenwadel, Jan" sort="Kazenwadel, Jan" uniqKey="Kazenwadel J" first="Jan" last="Kazenwadel">Jan Kazenwadel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Secker, Genevieve A" sort="Secker, Genevieve A" uniqKey="Secker G" first="Genevieve A." last="Secker">Genevieve A. Secker</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Betterman, Kelly L" sort="Betterman, Kelly L" uniqKey="Betterman K" first="Kelly L." last="Betterman">Kelly L. Betterman</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Medicine, University of Adelaide, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Harvey, Natasha L" sort="Harvey, Natasha L" uniqKey="Harvey N" first="Natasha L." last="Harvey">Natasha L. Harvey</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Medicine, University of Adelaide, Adelaide, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medicine, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Despite the importance of blood vessels and lymphatic vessels during development and disease, the signalling pathways underpinning vessel construction remain poorly characterised. Primary mouse endothelial cells have traditionally proven difficult to culture and as a consequence, few assays have been developed to dissect gene function and signal transduction pathways in these cells <italic>ex vivo</italic>
. Having established methodology for the purification, short-term culture and transfection of primary blood (BEC) and lymphatic (LEC) vascular endothelial cells isolated from embryonic mouse skin, we sought to optimise robust assays able to measure embryonic LEC proliferation, migration and three-dimensional tube forming ability <italic>in vitro</italic>
. In the course of developing these assays using the pro-lymphangiogenic growth factors FGF2 and VEGF-C, we identified previously unrecognised roles for FGFR1 signalling in lymphangiogenesis. The small molecule FGF receptor tyrosine kinase inhibitor SU5402, but not inhibitors of VEGFR-2 (SU5416) or VEGFR-3 (MAZ51), inhibited FGF2 mediated LEC proliferation, demonstrating that FGF2 promotes proliferation directly via FGF receptors and independently of VEGF receptors in primary embryonic LEC. Further investigation revealed that FGFR1 was by far the predominant FGF receptor expressed by primary embryonic LEC and correspondingly, siRNA-mediated FGFR1 knockdown abrogated FGF2 mediated LEC proliferation. While FGF2 potently promoted LEC proliferation and migration, three dimensional tube formation assays revealed that VEGF-C primarily promoted LEC sprouting and elongation, illustrating that FGF2 and VEGF-C play distinct, cooperative roles in lymphatic vascular morphogenesis. These assays therefore provide useful tools able to dissect gene function in cellular events important for lymphangiogenesis and implicate FGFR1 as a key player in developmental lymphangiogenesis <italic>in vivo</italic>
.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name>
</author>
<author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name>
</author>
<author><name sortKey="Sabine, A" uniqKey="Sabine A">A Sabine</name>
</author>
<author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnston, Mg" uniqKey="Johnston M">MG Johnston</name>
</author>
<author><name sortKey="Walker, Ma" uniqKey="Walker M">MA Walker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pepper, Ms" uniqKey="Pepper M">MS Pepper</name>
</author>
<author><name sortKey="Wasi, S" uniqKey="Wasi S">S Wasi</name>
</author>
<author><name sortKey="Ferrara, N" uniqKey="Ferrara N">N Ferrara</name>
</author>
<author><name sortKey="Orci, L" uniqKey="Orci L">L Orci</name>
</author>
<author><name sortKey="Montesano, R" uniqKey="Montesano R">R Montesano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gnepp, Dr" uniqKey="Gnepp D">DR Gnepp</name>
</author>
<author><name sortKey="Chandler, W" uniqKey="Chandler W">W Chandler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Djoneidi, M" uniqKey="Djoneidi M">M Djoneidi</name>
</author>
<author><name sortKey="Brodt, P" uniqKey="Brodt P">P Brodt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Borron, P" uniqKey="Borron P">P Borron</name>
</author>
<author><name sortKey="Hay, Jb" uniqKey="Hay J">JB Hay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clasper, S" uniqKey="Clasper S">S Clasper</name>
</author>
<author><name sortKey="Royston, D" uniqKey="Royston D">D Royston</name>
</author>
<author><name sortKey="Baban, D" uniqKey="Baban D">D Baban</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
<author><name sortKey="Ewers, S" uniqKey="Ewers S">S Ewers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kriehuber, E" uniqKey="Kriehuber E">E Kriehuber</name>
</author>
<author><name sortKey="Breiteneder Geleff, S" uniqKey="Breiteneder Geleff S">S Breiteneder-Geleff</name>
</author>
<author><name sortKey="Groeger, M" uniqKey="Groeger M">M Groeger</name>
</author>
<author><name sortKey="Soleiman, A" uniqKey="Soleiman A">A Soleiman</name>
</author>
<author><name sortKey="Schoppmann, Sf" uniqKey="Schoppmann S">SF Schoppmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bowman, Ca" uniqKey="Bowman C">CA Bowman</name>
</author>
<author><name sortKey="Witte, Mh" uniqKey="Witte M">MH Witte</name>
</author>
<author><name sortKey="Witte, Cl" uniqKey="Witte C">CL Witte</name>
</author>
<author><name sortKey="Way, Dl" uniqKey="Way D">DL Way</name>
</author>
<author><name sortKey="Nagle, Rb" uniqKey="Nagle R">RB Nagle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Way, D" uniqKey="Way D">D Way</name>
</author>
<author><name sortKey="Hendrix, M" uniqKey="Hendrix M">M Hendrix</name>
</author>
<author><name sortKey="Witte, M" uniqKey="Witte M">M Witte</name>
</author>
<author><name sortKey="Witte, C" uniqKey="Witte C">C Witte</name>
</author>
<author><name sortKey="Nagle, R" uniqKey="Nagle R">R Nagle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mancardi, S" uniqKey="Mancardi S">S Mancardi</name>
</author>
<author><name sortKey="Stanta, G" uniqKey="Stanta G">G Stanta</name>
</author>
<author><name sortKey="Dusetti, N" uniqKey="Dusetti N">N Dusetti</name>
</author>
<author><name sortKey="Bestagno, M" uniqKey="Bestagno M">M Bestagno</name>
</author>
<author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sironi, M" uniqKey="Sironi M">M Sironi</name>
</author>
<author><name sortKey="Conti, A" uniqKey="Conti A">A Conti</name>
</author>
<author><name sortKey="Bernasconi, S" uniqKey="Bernasconi S">S Bernasconi</name>
</author>
<author><name sortKey="Fra, Am" uniqKey="Fra A">AM Fra</name>
</author>
<author><name sortKey="Pasqualini, F" uniqKey="Pasqualini F">F Pasqualini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nisato, Re" uniqKey="Nisato R">RE Nisato</name>
</author>
<author><name sortKey="Harrison, Ja" uniqKey="Harrison J">JA Harrison</name>
</author>
<author><name sortKey="Buser, R" uniqKey="Buser R">R Buser</name>
</author>
<author><name sortKey="Orci, L" uniqKey="Orci L">L Orci</name>
</author>
<author><name sortKey="Rinsch, C" uniqKey="Rinsch C">C Rinsch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuo, M" uniqKey="Matsuo M">M Matsuo</name>
</author>
<author><name sortKey="Koizumi, K" uniqKey="Koizumi K">K Koizumi</name>
</author>
<author><name sortKey="Yamada, S" uniqKey="Yamada S">S Yamada</name>
</author>
<author><name sortKey="Tomi, M" uniqKey="Tomi M">M Tomi</name>
</author>
<author><name sortKey="Takahashi, R" uniqKey="Takahashi R">R Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ando, T" uniqKey="Ando T">T Ando</name>
</author>
<author><name sortKey="Jordan, P" uniqKey="Jordan P">P Jordan</name>
</author>
<author><name sortKey="Joh, T" uniqKey="Joh T">T Joh</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Jennings, Mh" uniqKey="Jennings M">MH Jennings</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamaguchi, T" uniqKey="Yamaguchi T">T Yamaguchi</name>
</author>
<author><name sortKey="Ichise, T" uniqKey="Ichise T">T Ichise</name>
</author>
<author><name sortKey="Iwata, O" uniqKey="Iwata O">O Iwata</name>
</author>
<author><name sortKey="Hori, A" uniqKey="Hori A">A Hori</name>
</author>
<author><name sortKey="Adachi, T" uniqKey="Adachi T">T Adachi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liersch, R" uniqKey="Liersch R">R Liersch</name>
</author>
<author><name sortKey="Nay, F" uniqKey="Nay F">F Nay</name>
</author>
<author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name>
</author>
<author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kreuger, J" uniqKey="Kreuger J">J Kreuger</name>
</author>
<author><name sortKey="Nilsson, I" uniqKey="Nilsson I">I Nilsson</name>
</author>
<author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name>
</author>
<author><name sortKey="Petrova, T" uniqKey="Petrova T">T Petrova</name>
</author>
<author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kono, T" uniqKey="Kono T">T Kono</name>
</author>
<author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name>
</author>
<author><name sortKey="Shimazu, C" uniqKey="Shimazu C">C Shimazu</name>
</author>
<author><name sortKey="Ueda, Y" uniqKey="Ueda Y">Y Ueda</name>
</author>
<author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M Takahashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicosia, Rf" uniqKey="Nicosia R">RF Nicosia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bruyere, F" uniqKey="Bruyere F">F Bruyere</name>
</author>
<author><name sortKey="Melen Lamalle, L" uniqKey="Melen Lamalle L">L Melen-Lamalle</name>
</author>
<author><name sortKey="Blacher, S" uniqKey="Blacher S">S Blacher</name>
</author>
<author><name sortKey="Roland, G" uniqKey="Roland G">G Roland</name>
</author>
<author><name sortKey="Thiry, M" uniqKey="Thiry M">M Thiry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Cp" uniqKey="Ng C">CP Ng</name>
</author>
<author><name sortKey="Helm, Cl" uniqKey="Helm C">CL Helm</name>
</author>
<author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Helm, Cl" uniqKey="Helm C">CL Helm</name>
</author>
<author><name sortKey="Fleury, Me" uniqKey="Fleury M">ME Fleury</name>
</author>
<author><name sortKey="Zisch, Ah" uniqKey="Zisch A">AH Zisch</name>
</author>
<author><name sortKey="Boschetti, F" uniqKey="Boschetti F">F Boschetti</name>
</author>
<author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name>
</author>
<author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name>
</author>
<author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M Yamamoto</name>
</author>
<author><name sortKey="Anisimov, A" uniqKey="Anisimov A">A Anisimov</name>
</author>
<author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kazenwadel, J" uniqKey="Kazenwadel J">J Kazenwadel</name>
</author>
<author><name sortKey="Michael, Mz" uniqKey="Michael M">MZ Michael</name>
</author>
<author><name sortKey="Harvey, Nl" uniqKey="Harvey N">NL Harvey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name>
</author>
<author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shayan, R" uniqKey="Shayan R">R Shayan</name>
</author>
<author><name sortKey="Karnezis, T" uniqKey="Karnezis T">T Karnezis</name>
</author>
<author><name sortKey="Tsantikos, E" uniqKey="Tsantikos E">E Tsantikos</name>
</author>
<author><name sortKey="Williams, Sp" uniqKey="Williams S">SP Williams</name>
</author>
<author><name sortKey="Runting, As" uniqKey="Runting A">AS Runting</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abramoff, Md" uniqKey="Abramoff M">MD Abramoff</name>
</author>
<author><name sortKey="Magelhaes, Pj" uniqKey="Magelhaes P">PJ Magelhaes</name>
</author>
<author><name sortKey="Ram, Sj" uniqKey="Ram S">SJ Ram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zudaire, E" uniqKey="Zudaire E">E Zudaire</name>
</author>
<author><name sortKey="Gambardella, L" uniqKey="Gambardella L">L Gambardella</name>
</author>
<author><name sortKey="Kurcz, C" uniqKey="Kurcz C">C Kurcz</name>
</author>
<author><name sortKey="Vermeren, S" uniqKey="Vermeren S">S Vermeren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name>
</author>
<author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name>
</author>
<author><name sortKey="Brakenhielm, E" uniqKey="Brakenhielm E">E Brakenhielm</name>
</author>
<author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name>
</author>
<author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Lk" uniqKey="Chang L">LK Chang</name>
</author>
<author><name sortKey="Garcia Cardena, G" uniqKey="Garcia Cardena G">G Garcia-Cardena</name>
</author>
<author><name sortKey="Farnebo, F" uniqKey="Farnebo F">F Farnebo</name>
</author>
<author><name sortKey="Fannon, M" uniqKey="Fannon M">M Fannon</name>
</author>
<author><name sortKey="Chen, Ej" uniqKey="Chen E">EJ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohammadi, M" uniqKey="Mohammadi M">M Mohammadi</name>
</author>
<author><name sortKey="Mcmahon, G" uniqKey="Mcmahon G">G McMahon</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Tang, C" uniqKey="Tang C">C Tang</name>
</author>
<author><name sortKey="Hirth, P" uniqKey="Hirth P">P Hirth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fong, Ta" uniqKey="Fong T">TA Fong</name>
</author>
<author><name sortKey="Shawver, Lk" uniqKey="Shawver L">LK Shawver</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Tang, C" uniqKey="Tang C">C Tang</name>
</author>
<author><name sortKey="App, H" uniqKey="App H">H App</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kirkin, V" uniqKey="Kirkin V">V Kirkin</name>
</author>
<author><name sortKey="Mazitschek, R" uniqKey="Mazitschek R">R Mazitschek</name>
</author>
<author><name sortKey="Krishnan, J" uniqKey="Krishnan J">J Krishnan</name>
</author>
<author><name sortKey="Steffen, A" uniqKey="Steffen A">A Steffen</name>
</author>
<author><name sortKey="Waltenberger, J" uniqKey="Waltenberger J">J Waltenberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shin, Jw" uniqKey="Shin J">JW Shin</name>
</author>
<author><name sortKey="Min, M" uniqKey="Min M">M Min</name>
</author>
<author><name sortKey="Larrieu Lahargue, F" uniqKey="Larrieu Lahargue F">F Larrieu-Lahargue</name>
</author>
<author><name sortKey="Canron, X" uniqKey="Canron X">X Canron</name>
</author>
<author><name sortKey="Kunstfeld, R" uniqKey="Kunstfeld R">R Kunstfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reilly, Jf" uniqKey="Reilly J">JF Reilly</name>
</author>
<author><name sortKey="Maher, Pa" uniqKey="Maher P">PA Maher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grand, Ek" uniqKey="Grand E">EK Grand</name>
</author>
<author><name sortKey="Chase, Aj" uniqKey="Chase A">AJ Chase</name>
</author>
<author><name sortKey="Heath, C" uniqKey="Heath C">C Heath</name>
</author>
<author><name sortKey="Rahemtulla, A" uniqKey="Rahemtulla A">A Rahemtulla</name>
</author>
<author><name sortKey="Cross, Nc" uniqKey="Cross N">NC Cross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bottcher, Rt" uniqKey="Bottcher R">RT Bottcher</name>
</author>
<author><name sortKey="Niehrs, C" uniqKey="Niehrs C">C Niehrs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stachowiak, Mk" uniqKey="Stachowiak M">MK Stachowiak</name>
</author>
<author><name sortKey="Fang, X" uniqKey="Fang X">X Fang</name>
</author>
<author><name sortKey="Myers, Jm" uniqKey="Myers J">JM Myers</name>
</author>
<author><name sortKey="Dunham, Sm" uniqKey="Dunham S">SM Dunham</name>
</author>
<author><name sortKey="Berezney, R" uniqKey="Berezney R">R Berezney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deng, Cx" uniqKey="Deng C">CX Deng</name>
</author>
<author><name sortKey="Wynshaw Boris, A" uniqKey="Wynshaw Boris A">A Wynshaw-Boris</name>
</author>
<author><name sortKey="Shen, Mm" uniqKey="Shen M">MM Shen</name>
</author>
<author><name sortKey="Daugherty, C" uniqKey="Daugherty C">C Daugherty</name>
</author>
<author><name sortKey="Ornitz, Dm" uniqKey="Ornitz D">DM Ornitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamaguchi, Tp" uniqKey="Yamaguchi T">TP Yamaguchi</name>
</author>
<author><name sortKey="Harpal, K" uniqKey="Harpal K">K Harpal</name>
</author>
<author><name sortKey="Henkemeyer, M" uniqKey="Henkemeyer M">M Henkemeyer</name>
</author>
<author><name sortKey="Rossant, J" uniqKey="Rossant J">J Rossant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pirvola, U" uniqKey="Pirvola U">U Pirvola</name>
</author>
<author><name sortKey="Ylikoski, J" uniqKey="Ylikoski J">J Ylikoski</name>
</author>
<author><name sortKey="Trokovic, R" uniqKey="Trokovic R">R Trokovic</name>
</author>
<author><name sortKey="Hebert, Jm" uniqKey="Hebert J">JM Hebert</name>
</author>
<author><name sortKey="Mcconnell, Sk" uniqKey="Mcconnell S">SK McConnell</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Kazenwadel, Jan" sort="Kazenwadel, Jan" uniqKey="Kazenwadel J" first="Jan" last="Kazenwadel">Jan Kazenwadel</name>
</noRegion>
<name sortKey="Betterman, Kelly L" sort="Betterman, Kelly L" uniqKey="Betterman K" first="Kelly L." last="Betterman">Kelly L. Betterman</name>
<name sortKey="Betterman, Kelly L" sort="Betterman, Kelly L" uniqKey="Betterman K" first="Kelly L." last="Betterman">Kelly L. Betterman</name>
<name sortKey="Harvey, Natasha L" sort="Harvey, Natasha L" uniqKey="Harvey N" first="Natasha L." last="Harvey">Natasha L. Harvey</name>
<name sortKey="Harvey, Natasha L" sort="Harvey, Natasha L" uniqKey="Harvey N" first="Natasha L." last="Harvey">Natasha L. Harvey</name>
<name sortKey="Secker, Genevieve A" sort="Secker, Genevieve A" uniqKey="Secker G" first="Genevieve A." last="Secker">Genevieve A. Secker</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004585 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004585 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3391274 |texte= In Vitro Assays Using Primary Embryonic Mouse Lymphatic Endothelial Cells Uncover Key Roles for FGFR1 Signalling in Lymphangiogenesis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22792354" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |